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This application report presents a ready-to-use USB connectivity reference design for MSP430 microcontrollers using the Texas Instruments TUSB3410 USB-to-serial bridge controller. The provided solution enables high-speed data transfers with speeds of up to 921,600 bit/s as well as MSP430 Flash code download through the USB port. The reference design includes MSP430 and PC software, drivers, schematics, layout, and BOM information.