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This application report helps to ease the migration from MSP430F2xx flash-based MCUs to the MSP430FR4xx and MSP430FR2xx FRAM-based MCUs. It discusses programming, system, hardware, core architecture, and peripheral considerations. The intent is to highlight key differences between the two families. For more information on the use of the MSP430FR4xx and MSP430FR2xx devices, see the MSP430FR4xx and MSP430FR2xx family user's guide. Although the MSP430F2xx and MSP430G2xx families are used as a base for comparison, similar considerations apply when migrating from MSP430F1xx and MSP430F4xx families. For the migration guide to MSP430FR57xx, see Migrating from the MSP430F2xx family to the MSP430FR57xx family.