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Operational amplifiers (Op Amps or OAs) are used extensively in sensing and measurement applications. MSP430 microcontrollers (MCUs) provide full signal chain implementation with the integrated Smart Analog Combo (SAC) to replace external Op Amps. The Smart Analog Combo is a configurable analog peripheral that includes a high-performance low-power Op Amp, a programmable gain amplifier (PGA) with gain up to 33, and a 12-bit digital-to-analog converter (DAC). This application report describes how to use the Smart Analog Combo module in MSP430 MCUs. Smart Analog Combo concept, operation modes, internal connection, ROM-based driver library, and design consideration are described. This application report also describes Smart Analog Combo use cases and the benefits of using the module in smoke detector and current loop applications.