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This application report describes differences between the Texas Instruments TMS320x281x and TMS320x280x/2801x/2804x DSPs to assist in application migration from the 281x to the 280x. While the main focus of this document is migration from 281x to 280x/2801x/2804x, users considering migrating in the reverse direction (280x to 281x) will also find this document useful. Functions that are identical in both devices are not necessarily included. All efforts have been made to provide a comprehensive list of the differences between the two device groups in the 28x generation.