AFE4900 Ultra-low-power integrated AFE for wearable optical, electrical biosensing |

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Ultra-low-power integrated AFE for wearable optical, electrical biosensing


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Full data sheet and other design resources are available. Request now


The AFE4900 device is an analog front-end (AFE) for synchronized electrocardiogram (ECG), photoplethysmogram (PPG) signal acquisition. The device can also be used for optical bio-sensing applications, such as heart-rate monitoring (HRM) and saturation of peripheral capillary oxygen (SpO2). The PPG signal chain supports up to four switching light-emitting diodes (LEDs) and up to three photodiodes (PDs). The LEDs can be switched on using a fully integrated LED driver. The current from the photodiode is converted into voltage by the transimpedance amplifier (TIA) and digitized using an analog-to-digital converter (ADC). The ECG signal chain has an instrumentation amplifier (INA) with a programmable gain that interfaces to the same ADC. A right-leg drive (RLD) amplifier set can be used to the bias for the ECG input pins. AC and dc lead-off detect schemes are supported. The ADC codes from the PPG and ECG phases can be stored in a 128-sample first in, first out (FIFO) block and read out using either an I2C or a serial programming interface (SPI) interface.


  • Synchronized PPG, ECG signal acquisition at data rates up to 1 kHz
  • ECG signal chain:
    • Standalone ECG acquisition up to 4 kHz
    • Input bias: 1-lead ECG with RLD bias
    • Programmable INA gain: 2.15 to 12.92
    • Input noise (1 Hz to 150 Hz): 2.5 µVrms at 1 kHz, 1.25 µVrms at 4-kHz data rate
    • AC, DC lead-off detect: 12.5-nA to 100-nA
    • IEC 60601 Test report available on request
  • PPG receiver:
    • Supports three time-multiplexed PD inputs
    • 24-Bit representation of current from PD
    • DC offset subtraction DAC (Up to ±126-µA) at TIA input for each LED, ambient
    • Digital ambient subtraction at ADC output
    • Noise filtering with programmable bandwidth
    • Transimpedance gain: 10 kΩ to 2 MΩ
    • Dynamic range up to 100 dB
    • Receiver operates in PPG-only mode at approximately 1-µA/Hz sampling rate
    • Power-down mode: approximately 0 µA
  • PPG transmitter:
    • Four LEDs in common anode configuration
    • 8-Bit LED current up to 200 mA
    • Mode to fire two LEDs in parallel
    • Programmable LED on-time
    • Simultaneous support of three LEDs for SpO2, or multiwavelength HRM
    • Average current of 30 µA adequate for a
      typical heart-rate monitoring scenario:
      • 20-mA Setting, 60-µs pulse duration,
        25-Hz sampling rate
  • Clocking using an external or internal clock
  • FIFO with 128-sample depth for ECG and PPG
  • I2C, SPI interfaces: selectable by pin
  • 2.6-mm × 2.1-mm, 0.4-mm Pitch DSBGA package
  • Supplies:
    • Rx: 1.8 V to 1.9 V (LDO bypass),
      2.0 V to 3.6 V (LDO enabled)
    • Tx: 3 V to 5.25 V
    • IO: 1.7 V to Rx_SUP

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Compare all products in Biosensing AFEs Email Download to Excel
Part number Order Number of input channels Resolution (Bits) Interface Number of LEDs Features Operating temperature range (C) Package Group Package size: mm2:W x L (PKG) Approx. price (US$)
AFE4900 Order now 3     24     SPI
4     Optical biosensing     -20 to 70         2.42 | 1ku    
AFE4300 Order now 2     16     SPI     0     Biosensing     0 to 70     LQFP | 80     80LQFP: 196 mm2: 14 x 14 (LQFP | 80)     1.50 | 1ku    
AFE4403 Order now 1     22     SPI     3     Optical biosensing     -20 to 70     DSBGA | 36     36DSBGA: 11 mm2: 3.25 x 3.25 (DSBGA | 36)     2.86 | 1ku    
AFE4404 Order now 1     24     I2C     3     Optical biosensing     -20 to 70     DSBGA | 15     See datasheet (DSBGA)     2.01 | 1ku    
AFE4405 Samples not available 2     24     I2C
3     Optical biosensing     -20 to 70         2.20 | 1ku    
AFE4410 Samples not available 3     24     SPI
4     Optical biosensing     -20 to 70         2.33 | 1ku    
AFE4420 Samples not available 4     24     I2C     4     Optical Biosensing     -40 to 85         3.61 | 1ku    
AFE4490 Order now 1     22     Serial SPI     2     Optical biosensing     -40 to 85     VQFN | 40     40VQFN: 36 mm2: 6 x 6 (VQFN | 40)     7.00 | 1ku    
AFE44S30 Samples not available 4     24     SPI     7     Optical Biosensing     -40 to 85         5.28 | 1ku