Product details


Applications 1-lead ECG, Dry electrode ECG, Impedance spectroscopy, Optical-HRM Number of input channels 4 Number of LEDs 8 Interface type SPI, I2C Operating temperature range (C) -40 to 85 open-in-new Find other Biosensing AFEs

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DSBGA (YBG) 42 8 mm² 3 x 2.6 open-in-new Find other Biosensing AFEs


  • Integrated signal chains for Bio-Z, EDA, ECG, PPG
  • Synchronized ECG, PPG enables PTT-based BP
  • Bio-Z signal chain
    • Multi-frequency Body impedance Analysis (BIA) with frequency programmable up to 250 kHz
    • Low frequency excitation mode for EDA/GSR
    • Complex (I,Q) Tetrapolar impedance measurement
    • Sine-wave excitation with a 7-bit DAC
    • Calibration scheme compensates for electrode impedance to achieve accurate Bio-Z
    • State machine for Automatic Calibration
  • ECG signal chain:
    • 1-lead ECG signal acquisition up to 2 kHz
    • INA gain programmable from 2-21
    • RLD output to set body bias through third electrode
    • Input noise (0.5-150 Hz): 0.75 µVrms at 1 kHz
    • ± 0.6 V differential DC offset and ± 0.3 V CM range
    • HPF with 0.4 Hz corner, quick saturation recovery
    • >1 GΩ input impedance, CMRR > 100 dB
    • Integrated 300 Hz anti-aliasing low pass filter
    • AC, DC lead-off detect: 1.6-nA to 100-nA
  • PPG signal chain
    • Supports acquisition of up to 24 PPG signals
    • Flexible allocation of 8 LED, 4 PD in each phase
    • Supports PPG sensors at different data rates
    • Optical loopback SNR of 100-dB, extendable to 110-dB with on-chip filtering
    • Low Current for Continuous Operation with a Typical Value: 15-µA for an LED, 15-µA for the Receiver
  • PPG Transmitter
    • 8-Bit Programmable LED Current with range adjustable from 25 mA to 250 mA
    • Programmable LED On-Time per-phase
    • Support of 8 LEDs in Common Anode
  • PPG Receiver
    • Supports 4 PDs, 2 parallel receive paths
    • Noise filtering with programmable bandwidth
    • Trans-impedance Gain: 3.7 kΩ to 1 MΩ
    • 8-bit Ambient Offset Subtraction DAC with range from16-256 µA
    • 8-bit LED Offset Subtraction DAC with range from 32 to 64 µA
    • Automatic ambient & LED DC cancellation
    • Supports external clock and internal oscillator modes
    • FIFO with 256-sample Depth
    • SPITM, I2C interfaces: Selectable by pin
    • Supplies: Rx:1.7-1.9V (LDO Bypass); 1.9 V to -3.6 V (LDO Enabled), Tx: 3 V to 5.5 V, IO:1.7-RX_SUP
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The AFE4500 is a versatile signal acquisition system that supports three signal chains. An impedance measurement signal chain with integrated excitation and sense can be used for applications like Bio-impedance analysis (BIA), Electro-dermal analysis (EDA) and Impedance spectroscopy.

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Technical documentation

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Type Title Date
* Data sheet AFE4500 Ultra-Small, Integrated AFE for Bio-Impedance Analysis, Electrical Bio-sensing and Optical Bio-sensing datasheet Apr. 07, 2021
User guide AFE4500 EVM User's Guide Feb. 15, 2021
Technical article Offset correction improves the next generation of heart-rate smart watches Aug. 24, 2015
Technical article A new way to illuminate the human condition Dec. 30, 2013
Technical article Oximeter signaling: There’s more than meets the eye Dec. 04, 2013
Technical article Virtual hospital implementation using a worn health monitor Nov. 13, 2013

Design & development

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Hardware development

document-generic User guide

The AFE4500 evaluation module (EVM) is designed to expedite evaluation and system-development activities related to the AFE4500. AFE4500 supports synchronized signal acquisition for photoplethysmogram (PPG), electrocardiogram (ECG), and body impedance analysis (BIA).

The analog-to-digital converter (...)

  • Acquire data at up to 1000 SPS in evaluation mode
  • USB-based power and PC application connectivity
  • Access to all AFE4500 registers
  • USB-based firmware upgrade option

Software development

B SECUR ECG algorithms and electrode design services
Provided by B Secur HeartKey is a powerful and accurate set of ECG algorithms, ready for integration into the next generation low power low memory consumer / IoT & medical devices such as smartwatches, smart clothing, medical, automotive, smart home devices and hand-held devices. HeartKey is comprised of advanced (...)

Design tools & simulation

PSpice® for TI design and simulation tool
PSPICE-FOR-TI — PSpice® for TI is a design and simulation environment that helps evaluate functionality of analog circuits. This full-featured, design and simulation suite uses an analog analysis engine from Cadence®. Available at no cost, PSpice for TI includes one of the largest model libraries in the (...)
  • Leverages Cadence PSpice Technology
  • Preinstalled library with a suite of digital models to enable worst-case timing analysis
  • Dynamic updates ensure you have access to most current device models
  • Optimized for simulation speed without loss of accuracy
  • Supports simultaneous analysis of multiple products
  • (...)

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