Product details


Applications Clinical fingertip pulse oximetry, SpO2 Number of input channels 1 Resolution (Bits) 22 Number of LEDs 3 Interface type SPI Operating temperature range (C) -20 to 70 open-in-new Find other Biosensing AFEs

Package | Pins | Size

DSBGA (YZP) 36 11 mm² 3.08 x 3.08 open-in-new Find other Biosensing AFEs


  • Fully-Integrated AFE for Pulse Oximeter and Heart Rate Monitoring Applications:
  • Transmit:
    • Integrated Dual LED Driver (H-Bridge or Common Anode)
    • Option for a Third LED Support for Optimized SPO2, HRM, or Multi-Wavelength HRM
    • Up to 110-dB Dynamic Range
    • LED Current:
      • Programmable to 100 mA with 8-Bit Current Resolution
    • 30 µA + Average LED Current
    • Programmable LED On-Time
    • Independent LED2 and LED1 Current Reference
  • Receive Channel with High Dynamic Range:
    • 22-Bit Output in Twos Complement Format
    • Up to 105-dB Dynamic Range
    • Low Power: < 650 µA
    • Dynamic Power-Down Mode to Reduce Current to 300 µA
    • Adaptable to a Very Wide Range of Signal Amplitudes:
      • Total Programmable Gain: 10 kΩ to 4 MΩ
    • Integrated Digital Ambient Estimation and Subtraction
  • Flexible Clocking by External Clock or Crystal:
    • Pulse Frequency: 62.5 SPS to 2000 SPS
    • Flexible Pulse sequencing and Timing Control
    • Input Clock Range: 4 MHz (Min) to 60 MHz (Max)
  • Integrated Fault Diagnostics:
    • Photodiode and LED Open and Short Detection
  • Supplies:
    • Rx = 2.0 V to 3.6 V
    • Tx = 3.0 V to 5.25 V
  • Package: Compact DSBGA-36 (3.07 mm × 3.07 mm × 0.5 mm)
  • Specified Temperature Range: 0°C–20°C to 70°C
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The AFE4403 is a fully-integrated analog front-end (AFE) ideally suited for pulse oximeter applications. The device consists of a low-noise receiver channel with an integrated analog-to-digital converter (ADC), an LED transmit section, and diagnostics for sensor and LED fault detection. The device is a very configurable timing controller. This flexibility enables the user to have complete control of the device timing characteristics. To ease clocking requirements and provide a low-jitter clock to the AFE4403, an oscillator is also integrated that functions from an external crystal. The device communicates to an external microcontroller or host processor using an SPI™ interface.

The device is a complete AFE solution packaged in a single, compact DSBGA-36 (3.07 mm × 3.07 mm × 0.5 mm) and is specified over the operating temperature range of –20°C to 70°C.

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Technical documentation

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Type Title Date
* Data sheet AFE4403 Ultra-Small, Integrated Analog Front-End for Heart Rate Monitors and Low-Cost Pulse Oximeters datasheet (Rev. C) Nov. 18, 2020
White paper Fortschrittliche Halbleitertechnologie für moderne Telemedizin-Anwendungen Oct. 28, 2020
White paper 持續進化的現代遠距照護應用半導 體技術 Oct. 28, 2020
White paper Evolving Semiconductor Technologies for Modern Telehealth Applications Oct. 26, 2020
Technical article Designing compact, efficient and high performing multiparameter patient monitors Jun. 25, 2019
Technical article Offset correction improves the next generation of heart-rate smart watches Aug. 24, 2015
Application note How to Design an SpO2 and OHRM System Using AFE4403 Mar. 02, 2015
User guide AFE4403EVM User's Guide (Rev. B) Jul. 21, 2014
Technical article A new way to illuminate the human condition Dec. 30, 2013
Technical article Oximeter signaling: There’s more than meets the eye Dec. 04, 2013

Design & development

For additional terms or required resources, click any title below to view the detail page where available.

Hardware development

document-generic User guide

The AFE4403EVM is intended for evaluating the AFE4403 device. The fully integrated AFE is ideally suited for Pulse Oximeter and Heart rate monitoring applications and consists of low noise receive channel, the LED transmit section and diagnostics for sensor and LED fault detection. The AFE4403 has a (...)

  • DB9 pulse oximeter sensor cable support
  • Acquire data at up to 3000 Hz in evaluation mode
  • USB based power and PC application connectivity
  • Access to all AFE4403 registers via an easy-to-use GUI
  • USB-based firmware upgrade option

Software development

Linux Driver for AFE4403
SLAC713.ZIP (52 KB)
SLAC677A.ZIP (5189 KB)
SLAC703.ZIP (4382 KB)
SLAC672B.ZIP (253590 KB)

Design tools & simulation

SBAM194.ZIP (28 KB) - IBIS Model
PSpice® for TI design and simulation tool
PSPICE-FOR-TI — PSpice® for TI is a design and simulation environment that helps evaluate functionality of analog circuits. This full-featured, design and simulation suite uses an analog analysis engine from Cadence®. Available at no cost, PSpice for TI includes one of the largest model libraries in the (...)
  • Leverages Cadence PSpice Technology
  • Preinstalled library with a suite of digital models to enable worst-case timing analysis
  • Dynamic updates ensure you have access to most current device models
  • Optimized for simulation speed without loss of accuracy
  • Supports simultaneous analysis of multiple products
  • (...)

Reference designs

Miniaturized Pulse Oximeter Reference Design
TIDA-00311 This reference design is for a miniturized pulse oximeter specifically designed for high end clinical applications. The small form factor module can easily simplify and accelerate pulse oximeter system design. Featuring TI's AFE4403 Analog Front End for interfacing with the LED and Photodiode (...)
document-generic Schematic document-generic User guide
Miniaturized Optical Heart Rate Reference Design
TIDA-00301 This reference design is for a miniaturized Optical Heart Rate Monitor measurement solution (no chest strap!) specifically targeted for wearable and mobile applications. The small form factor module can easily interface to smartphones, tablets, and wearables. With TI's AFE4403 AFE, you can (...)
document-generic Schematic

CAD/CAE symbols

Package Pins Download
DSBGA (YZP) 36 View options

Ordering & quality

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  • MSL rating/Peak reflow
  • MTBF/FIT estimates
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  • Qualification summary
  • Ongoing reliability monitoring

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