Product details

Applications Optical-HRM Number of input channels 2 Resolution (Bits) 24 Number of LEDs 3 Interface type I2C, SPI Operating temperature range (C) -20 to 70
Applications Optical-HRM Number of input channels 2 Resolution (Bits) 24 Number of LEDs 3 Interface type I2C, SPI Operating temperature range (C) -20 to 70
  • Transmitter:
    • Supports Common Anode LED Configuration
    • Dynamic Range: 100 dB
    • 8-Bit Programmable LED Current to 50 mA (Extendable to 100 mA)
    • Programmable LED On-Time
    • Simultaneous Support of 3 LEDs for Optimized SpO2, HRM, or Multi-Wavelength HRM
  • Receiver:
    • Supports 2 Time-Multiplexed Photodiode Inputs
    • 24-Bit Representation of the Current Input from the Photodiode in Twos Complement Format
    • Individual DC Offset Subtraction DAC
      (±15.75-µA Range) at TIA Input for Each LED, Ambient
    • Digital Ambient Subtraction at ADC Output
    • Transimpedance Gain: 10 kΩ to 2 MΩ
    • Dynamic Range: 100 dB
    • Dynamic Power-Saving Mode to Reduce Receiver Current to 200 µA
  • Pulse Frequency: 5 SPS to 1000 SPS
  • Flexible Pulse Sequencing and Timing Control
  • Flexible Clock Options:
    • External Clocking:
      4-MHz to 60-MHz Input Clock
    • Internal Clocking: 4-MHz Oscillator
  • FIFO with 240 Sample Depth:
    • Programmable Partitioning Across Phases
  • I2C, SPI Interfaces: Selectable by Pin
  • Operating Temperature Range: –20°C to +70°C
  • 2.6-mm × 2.1-mm DSBGA, 0.4-mm Pitch
  • Supplies: Rx: 2 V to 3.6 V, Tx: 3 V to 5.25 V,
    IO: 1.8 V to 3.6 V
  • Transmitter:
    • Supports Common Anode LED Configuration
    • Dynamic Range: 100 dB
    • 8-Bit Programmable LED Current to 50 mA (Extendable to 100 mA)
    • Programmable LED On-Time
    • Simultaneous Support of 3 LEDs for Optimized SpO2, HRM, or Multi-Wavelength HRM
  • Receiver:
    • Supports 2 Time-Multiplexed Photodiode Inputs
    • 24-Bit Representation of the Current Input from the Photodiode in Twos Complement Format
    • Individual DC Offset Subtraction DAC
      (±15.75-µA Range) at TIA Input for Each LED, Ambient
    • Digital Ambient Subtraction at ADC Output
    • Transimpedance Gain: 10 kΩ to 2 MΩ
    • Dynamic Range: 100 dB
    • Dynamic Power-Saving Mode to Reduce Receiver Current to 200 µA
  • Pulse Frequency: 5 SPS to 1000 SPS
  • Flexible Pulse Sequencing and Timing Control
  • Flexible Clock Options:
    • External Clocking:
      4-MHz to 60-MHz Input Clock
    • Internal Clocking: 4-MHz Oscillator
  • FIFO with 240 Sample Depth:
    • Programmable Partitioning Across Phases
  • I2C, SPI Interfaces: Selectable by Pin
  • Operating Temperature Range: –20°C to +70°C
  • 2.6-mm × 2.1-mm DSBGA, 0.4-mm Pitch
  • Supplies: Rx: 2 V to 3.6 V, Tx: 3 V to 5.25 V,
    IO: 1.8 V to 3.6 V

The AFE4405 is an analog front-end (AFE) for optical bio-sensing applications, such as heart-rate monitoring (HRM) and saturation of peripheral capillary oxygen (SpO2). The device supports three switching light-emitting diodes (LEDs) and up to two photodiodes. The current from the photodiode is converted into voltage by the transimpedance amplifier (TIA) and digitized using an analog-to-digital converter (ADC). The ADC code can be stored in a 240-sample first in, first out (FIFO) block with programmable depth. The FIFO depth can be partitioned to accommodate the phases that must be stored. The FIFO can be read out using either an I2C or a SPI interface. The AFE also has a fully-integrated LED driver with an 8-bit current control. The device has a high dynamic range transmit-and-receive circuitry that helps with the sensing of very small signal levels.

To request a full data sheet or other design resources: request AFE4405


The AFE4405 is an analog front-end (AFE) for optical bio-sensing applications, such as heart-rate monitoring (HRM) and saturation of peripheral capillary oxygen (SpO2). The device supports three switching light-emitting diodes (LEDs) and up to two photodiodes. The current from the photodiode is converted into voltage by the transimpedance amplifier (TIA) and digitized using an analog-to-digital converter (ADC). The ADC code can be stored in a 240-sample first in, first out (FIFO) block with programmable depth. The FIFO depth can be partitioned to accommodate the phases that must be stored. The FIFO can be read out using either an I2C or a SPI interface. The AFE also has a fully-integrated LED driver with an 8-bit current control. The device has a high dynamic range transmit-and-receive circuitry that helps with the sensing of very small signal levels.

To request a full data sheet or other design resources: request AFE4405


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Technical documentation

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Type Title Date
* Data sheet AFE4405 Ultra-Small, Integrated AFE with FIFO for Wearable, Optical Heart-Rate Monitoring and Bio-Sensing datasheet (Rev. C) 31 Jul 2019
User guide AFE4405EVM Introduction User's Guide 13 Apr 2016
Technical article Offset correction improves the next generation of heart-rate smart watches 24 Aug 2015
Technical article A new way to illuminate the human condition 30 Dec 2013
Technical article Oximeter signaling: There’s more than meets the eye 04 Dec 2013
Technical article Virtual hospital implementation using a worn health monitor 13 Nov 2013

Design & development

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Evaluation board

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The AFE4403EVM is intended for evaluating the AFE4403 device. The fully integrated AFE is ideally suited for Pulse Oximeter and Heart rate monitoring applications and consists of low noise receive channel, the LED transmit section and diagnostics for sensor and LED fault detection. The AFE4403 has a (...)

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Evaluation board

AFE4405EVM — AFE4405 Integrated AFE With FIFO for Wearable Optical Heart-Rate Monitoring Evaluation Module

The AFE4405 is an analog front-end (AFE) for optical bio-sensing applications, such as heart-rate monitoring (HRM) and saturation of peripheral capillary oxygen (SpO2). The device supports three switching light-emitting diodes (LEDs) and a single photodiode. The current from the photodiode is (...)

Evaluation board

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The AFE44x0SPO2EVM is intended for evaluating AFE4400 and AFE4490 devices. The family of devices are fully integrated AFE ideally suited for Pulse Oximeter applications and consist of low noise receive channel, the LED transmit section and diagnostics for sensor and LED fault detection. The (...)

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PSPICE-FOR-TI — PSpice® for TI design and simulation tool

PSpice® for TI is a design and simulation environment that helps evaluate functionality of analog circuits. This full-featured, design and simulation suite uses an analog analysis engine from Cadence®. Available at no cost, PSpice for TI includes one of the largest model libraries in the (...)
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