The AFE4960 is a analog front end for ECG that enables 3/5 lead applications such as Holter, AED, and ECG patches.  The AFE4960 supports synchronized signal acquisition of ECG and bio-impedance signals. The AFE can be configured as either a 2-channel ECG receiver or as a 1-channel ECG receiver and a Respiration impedance channel. The AFE signal chains can interface in a flexible manner to up to 4 electrodes. A Right leg drive (RLD) amplifier output, steerable to any of the electrodes can be used to set body bias. The AFE has AC and DC Lead biasing and lead on/off detection. Pacemaker pulse detection is supported on one channel. Programmable decimation filters at the output of both channels help reduce the output data rate.