The TLC3x2 input and output ESD protection contains a conventional diode-type "upper" ESD clamp between the I/O pins and V+, and a "lower" ESD clamp between the I/O pins and V-. The inputs or output must not exceed the supply rails by more than 300mV. TI does not recommend applying signals to the inputs with no supply voltage.

When the inputs are connected to a low impedance source, such as a power supply or buffered reference line, add a current-limiting resistor in series with the input to limit any currents when the clamps conduct. The current must be limited 10mA or less, though TI recommends limitng the current to 1mA or less. This series resistance can be part of any resistive input dividers or networks.