Wearable, 16-phase multi-sensor SpO2 and heart rate monitor (HRM) reference design with Bluetooth® 5


Design files


This reference design enables a wearable, optimized saturation of peripheral capillary oxygen (SpO2) and multi-sensor, multi-wavelength optical heart rate monitor (HRM). It uses AFE4420 device, which is a single-chip, bio-sensing front end for photoplethysmography (PPG) measurements. It supports up to four switching light-emitting diodes (LEDs) and up to four photodiodes to enable signal acquisition of up to 16 Phases. The CC2640R2F device (supporting Bluetooth® low energy 4.2 and 5) transfers the measured data to a remote location. This patient-monitoring design uses a single CR3032 battery with a 30-day life cycle. Raw data is available to calculate heart rate, SpO2, and other related parameters. 2 onboard light-emitting diodes (LEDs) identify low-battery detection and a Bluetooth connection.

  • Provides raw data to calculate heart rate, SpO2, and other related parameters
  • Uses single-chip, bio-sensing, front-end AFE4420 device for PPG measurement
    • Supports up to 4 LEDs and 4 photodiodes with ambient subtraction to improve signal-to-noise ratio (SNR)
    • Enables signal acquisition of up to 16 phases and multi-wavelength measurements with the flexible allocation of LEDs and photodiodes in each phase
  • Integrated Arm® Cortex®-M3 and 2.4-GHz RF transceiver (CC2640R2F) supports wireless data transfer through Bluetooth® low energy 4.2 and 5.0
  • Operates from CR3032 (3-V, 500-mA coin cell battery) with a battery life of 30 days using highly efficient DC/DC converters
  • Small form factor helps in easy adaption to wearable applications
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A fully assembled board has been developed for testing and performance validation only, and is not available for sale.

Design files & products

Design files

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Reference design overview and verified performance test data


Detailed schematic diagram for design layout and components


Complete listing of design components, reference designators, and manufacturers/part numbers


Detailed overview of design layout for component placement

TIDRXB3.ZIP (2741 K)

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Design file that contains information on physical board layer of design PCB


PCB layer plot file used for generating PCB design layout


Includes TI products in the design and potential alternatives.

Biosensing AFEs

AFE4420Ultra-small integrated AFE with FIFO for multisensor wearable optical heart-rate monitoring

Data sheet: PDF | HTML
Boost converters (integrated switch)

TPS610990.7Vin Synchronous Boost Converter with 800 nA Ultra-Low Quiescent Current

Data sheet: PDF | HTML
Buck-boost, inverting & split-rail converters (integrated switch)

TPS63036High Efficient Single Inductor Buck-Boost Converter with 1-A Switches

Data sheet: PDF | HTML
Buck-boost, inverting & split-rail converters (integrated switch)

TPS639001.8-V to 5.5-V, 75-nA IQ buck-boost converter with input current limit and Dynamic Voltage Scaling

Data sheet: PDF | HTML
Buck-boost, inverting & split-rail converters (integrated switch)

TPS639015.5-V buck-boost converter with 75-nA operating IQ in WCSP package

Data sheet: PDF | HTML
Low-power 2.4-GHz products

CC2640R2FSimpleLink™ 32-bit Arm® Cortex®-M3 Bluetooth® 5.1 Low Energy wireless MCU with 128-kB flash

Data sheet: PDF

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Technical documentation

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Type Title Date
* Design guide Wearable, 16-phase multi-sensor SpO2 and HRM ref design with Bluetooth® 5 (Rev. A) Mar. 17, 2019
Technical article Going beyond traditional SpO2 measurement with multiwavelength optical measurement PDF | HTML Feb. 12, 2019
Application note Measuring CC13xx and CC26xx current consumption (Rev. D) PDF | HTML Jan. 10, 2019
Application note How to Design an SpO2 and OHRM System Using AFE4403 Mar. 02, 2015

Related design resources

Hardware development

LAUNCHXL-CC2640R2 CC2640R2 LaunchPad™ development kit for SimpleLink™ Bluetooth® Low Energy wireless MCU

Reference designs

TIDA-010043 Efficient, high-current, linear LED driver reference design for SpO2 and other medical applications TIDA-01580 Wireless ECG, SpO2, PTT and heart rate monitor reference design for medical and consumer wearables

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