SLLU149E June 2011 – February 2016 TUSB7320 , TUSB7340
WAKE# and CLKREQ# pins are high impedance (~4.5 MΩ) pins and a positive constant current of 1 µA flowing into the pins could develop 4.5 V at the pin. When the VDD33 is at 0 V the pin can be overstressed and cause permanent leakage.
Care should be taken on pins WAKE# and CLKREQ# when VDD33 is at 0 V. If a voltage over 4.6 V is applied to these pins when VDD33 = 0, the pins could be degraded causing a leakage current. 4.6-V is above the maximum rated voltage (VDD33 + 0.5) and above the maximum operating voltage of 3.3 V.
This stress condition does not occur in normal operation mode where the maximum voltage that could be seen at WAKE# is 3.6 V.