AFE4410 Ultra-Small Integrated AFE With FIFO for Wearable Optical Heart-Rate Monitoring and Biosensing |

AFE4410 (ACTIVE) Ultra-Small Integrated AFE With FIFO for Wearable Optical Heart-Rate Monitoring and Biosensing


Recommended alternative parts

  • AFE4405  - The device has SIMILAR FUNCTIONALITY but is not functionally equivalent to the compared device. 

More Information

Full data sheet and other design resources are available under NDA. Request now


The AFE4410 is an analog front-end for optical biosensing applications, such as heart-rate monitoring (HRM). The device supports up to four switching light-emitting diodes (LEDs) and up to three photodiodes (PDs). The current from the photodiode is converted into voltage by the transimpedance amplifier (TIA) and digitized using an analog-to-digital converter (ADC). The ADC code is stored in a 128-sample first in, first-out block (FIFO) with programmable depth. The FIFO can be read out using either an I2C interface or a serial peripheral interface (SPI). The AFE also has a fully integrated LED driver with 8-bit current control. The device has high dynamic range transmit-and-receive circuitry offering a dynamic range of up to 100 dB that enables accurate heart-rate sensing. The AFE achieves extremely low current levels by operating an ultralow power (ULP) mode set by using the ENABLE_ULP register bit.


  • Accurate, Continuous Heart-Rate Monitoring:
    • Up to 100-dB Dynamic Range for Accurate Heart-Rate Detection
    • Low Current for Continuous Operation on a Wearable Device With a Typical Value:
      • 30 µA for an LED, 25 µA for the Receiver
  • Transmitter:
    • 4 LEDs in Common Anode Configurations
    • 8-Bit Programmable LED Current to 200 mA
    • Mode to Fire Two LEDs in Parallel
    • Programmable LED On-Time
    • Simultaneous Support of 3 LEDs for Optimized SpO2, HRM, or Multiwavelength HRM
    • Average Current of 30 µA Adequate for a Typical Heart-Rate Monitoring Scenario:
      • 20-mA Setting, 60-µs Pulse Duration,
        25-Hz Sampling Rate
  • Receiver:
    • Supports 3 Time-Multiplexed PD Inputs
    • 24-Bit Representation of Current Input From PD in Two’s-Complement Format
    • Individual DC Offset Subtraction DAC
      (Up to ±127-µA Range) at TIA Input for Each LED, Ambient
    • Digital Ambient Subtraction at ADC Output
    • Transimpedance Gain: 10 kΩ to 2 MΩ
    • Noise Filtering With Programmable Bandwidth
    • Receiver Operates at Approximately 1-µA/Hz Sampling Rate (Example, 25 µA at 25 Hz)
    • Hardware Power-Down Mode: Approximately 0-µA Current
  • Flexible Pulse Sequencing and Timing Control
  • Clocking Via External Clock or Internal Oscillator
  • FIFO With 128-Sample Depth:
    • Programmable Partitioning Across Phases
  • Pin-Selectable I2C, SPI Interface
  • Operating Temperature Range: –20°C to +70°C
  • 2.6-mm × 2.1-mm, 0.4-mm Pitch DSBGA Package
  • Supplies:
    • Tx: 3 V to 5.25 V
    • Rx: 1.8 V to 1.9 V (LDO Bypass),
      2.0 V to 3.6 V (LDO Enabled)
    • IO: 1.7 V to Rx_SUP

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Compare all products in Biosensing AFEs Email Download to Excel
Part number Order Number of input channels Resolution (Bits) Interface Number of LEDs Features Operating temperature range (C) Package Group Package size: mm2:W x L (PKG) Approx. price (US$)
AFE4410 Order now 3     24     SPI
4     Optical biosensing     -20 to 70         2.65 | 1ku    
AFE4403 Order now 1     22     SPI     3     Optical biosensing     -20 to 70     DSBGA | 36     See datasheet (DSBGA)     3.25 | 1ku    
AFE4404 Order now 1     24     I2C     3     Optical biosensing     -20 to 70     DSBGA | 15     See datasheet (DSBGA)     2.28 | 1ku    
AFE4405 Samples not available 2     24     I2C
3     Optical biosensing     -20 to 70         2.50 | 1ku    
AFE4420 Samples not available 4     24     I2C     4     Optical Biosensing     -40 to 85         4.10 | 1ku    
AFE4490 Order now 1     22     Serial SPI     2     Optical biosensing     -40 to 85     VQFN | 40     40VQFN: 36 mm2: 6 x 6 (VQFN | 40)     7.95 | 1ku    
AFE4900 Samples not available 3     24     SPI
4     Optical biosensing     -20 to 70         2.75 | 1ku