In many applications that are susceptible to common mode interference, higher speed communications are typically implemented and the multiplexer must be able to pass these signals unattenuated. The bandwidth specification found in all TI multiplexer data sheets can give an indication of the frequency of signals that can be handled by the multiplexer so they can be passed without issue. A good rule of thumb is to select a multiplexer that can handle a bandwidth of at least 1.5x-3x the application requirement to allow for margin in the design for layout and loading constraints.

At higher frequencies, there is also concern about channel to channel crosstalk. Crosstalk is defined as the magnitude of the signal of an ON-channel that appears on an adjacent channel. This can cause errors in any measurements or can introduce noise on adjacent lines that can negatively impact communications if the multiplexer does not have very good crosstalk performance.